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Adapting the Microenvironment to Regulate Leukocyte Function

Mia Phillipson

 

The local microenvironment greatly influences on recruitment and function of immune cells, and we investigate means to shift this environment depending on demand to enhance bacterial clearance, angiogenesis or induce immune-privilege. To understand the role of distinct immune cells in blood vessel formation we have developed a model where we can visualize and track immune cells in parallel to ongoing angiogenesis.

MiaP cartoon The leukocyte recruitment cascade (adapted from Phillipson and Kubes, Nat Med 2011)

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